Nussbaum: Thompson & Thompson Genetics in Medicine, 8th Edition

Chapter 02: Introduction to the Human Genome

Test Bank

MULTIPLE CHOICE

1.	How many chromosomes do humans normally have in their somatic cells?
A.	22	
B.	23	
C.	44	
D.	45	
E.	46	

ANS:	E

2.	In humans, DNA is associated with several classes of proteins and packaged into complexes known as:
A.	Histones	
B.	Chromatin	
C.	Nuclei	
D.	Genomes	
E.	Double helices	

ANS:	B

3.	Which of the following represents the pairing of nucleotide bases in DNA?
A.	Purines-Purines, Pyrimidines-Pyrimidines	
B.	Adenine-Cytosine, Guanine-Thymine	
C.	Adenine-Guanine, Cytosine-Thymine	
D.	Guanine-Cytosine, Adenine-Thymine	
E.	Deoxyribose-Ribose	

ANS:	D

4.	Which of the following are composed of repetitive DNA elements?
A.	Centromeres	
B.	Alu elements	
C.	LINE elements	
D.	Telomeres	
E.	All of the above
	
ANS:	E

5.	A human somatic cell spends most of its life in this state:
A.	Meiosis	
B.	Mitosis	
C.	Interphase	
D.	Zygote	
E.	Prophase	

ANS:	C

6.	The arms of a chromosome are designated:
A.	1 and 2	
B.	Short and long	
C.	p and q	
D.	Individually for each chromosome	
E.	A and B	

ANS:	C

7.	An important and distinct feature of meiosis is:
A.	Recombination	
B.	Chromosome condensation	
C.	Chromosome congression	
D.	Spindle formation	

ANS:	A

8.	Mitosis and meiosis result in the following chromosome complements, respectively:
A.	n, 2n	
B.	2n, n	
C.	Haploid, diploid	
D.	2n, 2n	
E.	n, n	

ANS:	B

9.	Failure of homologous chromosomes to segregate to opposite poles during meiosis is called:
A.	Disjunction	
B.	Missegregation	
C.	Nondisjunction	
D.	Meiotic failure	
E.	Nonsegregation	

ANS:	C

10.	In human males, when is meiosis initiated and completed?
A.	At birth, at ejaculation	
B.	At puberty, at ejaculation	
C.	At birth, at puberty	
D.	At puberty, it is continuous	
E.	At birth, it is continuous	

ANS:	D

11.	In human females, when is meiosis initiated and completed?
A.	At birth, at ovulation	
B.	At birth, it is continuous	
C.	At puberty, at fertilization	
D.	Prenatally, at ovulation	
E.	Prenatally, at fertilization	

ANS:	E

MULTIPLE RESPONSE

1.	The extent of the haplotype block surrounding a disease mutation depends on which two of the following factors?
A.	Marker phasing	
B.	Marker association	
C.	Recombination frequency in the region	
D.	Number of generations since the disease mutation arose	
E.	Marker repulsion	

ANS:	C, D 

Test Bank Files: